The 'I Am Cait' star, 66, who was formerly known as Bruce Jenner prior to her gender transition surgery earlier this year, has secured a place on the annual list alongside Victoria Beckham, 41, and Reese Witherspoon, 39.
The former Olympian - who has been married three times, including to Kardashian matriarch Kris Jenner, and has six children - said after securing a spot on the list: "I am just excited about the future for the first time in a long, long time.
"And that is a nice feeling to have.... To be honest with you, if the worst thing in the world that happens to you is you are trans, you've got it made."
Caitlyn, Victoria and Reese will join Misty Copeland, Elizabeth Holmes, Cecile Richards, the Women of Charleston, and the US women's national soccer team as they are honoured at 25th Anniversary Women of the Year Awards, which will be held in New York, on November 9.
The glamorous ceremony, which will take place at the Carnegie Hall, will be opened by comedienne Amy Schumer, and the gongs will be handed out on the night by Glamour Editor-in-Chief, Cindi Leive.
Meanwhile, this isn't the first time Caitlyn has received an award since her surgery as she also became a national advocate for transgender awareness and took home the Arthur Ashe Courage Award in July this year.