Michael Bent, Marty Moore, Andrew Trimble, Felix Jones and Fergus Mc Fadden have been left out.
Eoin Reddan and Conor Murray are the only specialist scrum half's as Darren Cave has been brought as cover for centre.
Wexford's Tadhg Furlong who only made his debut at the weekend has made it.
The squad is made up of 17 Forwards and 14 Backs and will be captained by Paul O'Connell who is the most capped player in the Ireland group with 103 caps.
Seventeen players will make their tournament debuts at Rugby World Cup 2015 - Darren Cave, Luke Fitzgerald, Tadhg Furlong, Iain Henderson, Chris Henry, Robbie Henshaw, Paddy Jackson, Dave Kearney, Ian Madigan, Jack McGrath, Jordi Murphy, Peter O'Mahony, Jared Payne, Richardt Strauss, Devin Toner, Nathan White and Simon Zebo.
Ireland Rugby World Cup 2015 Squad
Rory Best (Banbridge/Ulster) 84
Sean Cronin (St. Mary's College/Leinster) 45
Tadhg Furlong (Clontarf/Leinster) 1
Cian Healy (Clontarf/Leinster) 51
Jamie Heaslip (Dublin University/Leinster) 74
Iain Henderson (Ballynahinch/Ulster) 19
Chris Henry (Malone/Ulster) 18
Jack McGrath (St. Mary's College/Leinster) 19
Jordi Murphy (Lansdowne/Leinster) 12
Sean O'Brien (UCD/Leinster) 36
Paul O'Connell (Young Munster) 103 captain
Peter O'Mahony (Cork Constitution/Munster) 31
Mike Ross (Clontarf/Leinster) 51
Donnacha Ryan (Shannon/Munster) 30
Richardt Strauss (Old Wesley/Leinster) 9
Devin Toner (Lansdowne/Leinster) 26
Nathan White (Connacht) 2
Tommy Bowe (Belfast Harlequins/Ulster) 62
Darren Cave (Belfast Harlequins/Ulster) 9
Keith Earls (Young Munster/Munster) 41
Luke Fitzgerald (Blackrock College/Leinster) 30
Robbie Henshaw (Buccaneers/Connacht) 11
Paddy Jackson (Dungannon/Ulster) 12
David Kearney (Lansdowne/Leinster) 9
Rob Kearney (UCD/Leinster) 63
Ian Madigan (Blackrock College/Leinster) 20
Conor Murray (Garryowen/Munster) 36
Jared Payne (Ulster) 7
Eoin Reddan (Old Crescent/Leinster) 63
Jonathan Sexton (St Mary's College/Leinster) 52
Simon Zebo (Cork Constitution/Munster) 17