Gardai are appealing for witnesses following a serious one-vehicle collision on the main Moville - Derry Road.
The crash occurred at approximately 12.30 this morning.
The driver, a man in his 20s, is said to be in a serious condition.
He was initially treated in Altnagelvin hospital but has been since transferred to the Royal Victoria Hospital in Belfast.
Two females were also involved in the crash and were also treated in hospital. Their condition is unknown at this stage.
The main Moville-Derry road will remain closed for most of today and road diversions are in place.