O’Neill comes in for Omagh club-mate Barry Tierney in one of two changes made by manager Mickey Harte from the team that started against Donegal in the Ulster Championship preliminary round.
Tiernan McCann returns to the starting fifteen, with U21 star Cathal McShane dropping to the bench.
Mattie Donnelly moves from centre forward to midfield, with both O’Neill and McCann posted in the half forward line.
Goalkeeper Mickey O’Neill holds on to his place ahead of Niall Morgan, following his superb display in the three points defeat to Donegal.
Tyrone: M O’Neill, A McCrory, R McNamee, C McCarron, R McNabb, Justin McMahon, P Harte, C Cavanagh, M Donnelly, T McCann, R O’Neill, R Brennan, D McCurry, S Cavanagh, C McAliskey.