Peter Harte returns from injury and replaces Barry Tierney at left half back, while Tiernan McCann comes into the half forward line for PJ Lavery.
Tyrone are looking for their first win in the league after last weekend's defeat to Monaghan.
Mickey Harte's side have taken victory in their last two encounters against Mayo in the league.
The Tyrone starting 15.
1 - Niall Morgan - Éadan na dTorc
2 - Aidan McCrory - Aireagal Chiaráin,
3 - Ronan McNamee - Achadh Uí Aráin,
4 - Cathal McCarron - An Droim Mór
5 - Ronan McNabb - An Droim Mór
6 - Mattie Donnelly - Trí Leac
7 - Peter Harte - Aireagal Chiaráin
8 - Colm Cavanagh - An Mhaigh
9 - Padraig McNulty - Dún Geanainn
10 - Tiernan McCann - Coill an Chlochair
11 - Ronan O Neill - An Omaigh
12 - Peter Hughes - Eiscreach
13 - Darren McCurry - Éadan na dTorc
14 - Sean Cavanagh © - An Mhaigh
15 - Niall McKenna - An Domhnach Mór