Mattie Donnelly and Ronan O’Neill, who have already played for Ulster University in the competition, will both start at the Atheltic Grounds, now eligible following the elimination of their college side.
Sean Cavanagh and defender Dwayne Quinn are the only players to hold on to their places following the seven points win over Antrim last weekend.
Conal McCann, younger brother of Tiernan McCann, makes his debut at midfield, while attacker PJ Quinn makes his first start of the year.
And Joe McMahon returns to the squad, and is listed among the substitutes for the eagerly awaited re-match of the season opener, a feisty contest which producved 19 cards, four of them red.
Tyrone: M O’Neill, D Quinn, R McNamee, R McKenna, R Brennan, M Donnelly, P Harte, C avanagh, C McCann, PJ Lavery, R O’Neill, P Hughes, S McGuigan, S Cavanagh, C McShane.