Jared Payne will play at full back for the first time this season with Louis Luidik replacing Bowe on the right wing.
Lock Franco van der Merwe is back having recovered from a chest infection.
Michael Allen starts on the left wing while there's a new front row featuring Andrew Warwick, Rob Herring and Bronson Ross.
Centre Darren Cave makes his 150th appearance for Ulster tomorrow.
Ulster are bottom of Pool 3 with one win from four games.