The crash happened on the Drumquin Road in Castlederg on Monday afternoon.
The injured man was taken to Altnagelvin Hospital for treatment.
The road has been closed in both directions following the incident.
PSNI Inspector Sam Shearer added: "Police have diverted traffic travelling from Drumquin to Castlederg along the Kirlish Road and traffic travelling from Castlederg towards Drumquin are being diverted along the Drumgallan Road.
"I would advise motorists that these are both minor roads and they should exercise caution.
"There are no further details at this stage."