Officers found six pipe bombs, 500kg of fertiliser and home-made explosives packs during a four-day security operation at a farmhouse in Kinawley.
The man has been charged with possession of explosives and ammunition as well as possession of articles likely to be of use to terrorists.
He is due to appear in court later.
The PSNI said bomb timers, detonators and fuses were also seized during the search, along with a gun, 100 rounds of ammunition and forensic suits and gloves.
Police have linked the weapons to dissident republicans.
Officers began searches of buildings, vehicles and fields at the farm on Wednesday.
It is in a remote spot off a quiet road close to the border with the Republic of Ireland.
Neighbours said they heard what sounded like three controlled explosions on Friday evening. They said there had been no sign of activity at the farm before the security operation.