Rory Patterson, Shaun Kelly and Aaron Barry are all sidelined for the game.
Patterson suffered slight concussion in Tuesday's cup win over Shamrock Rovers, Barry has a knee injury and Kelly is suspended.
Ryan McBride, Barry McNamee and Philip Lowry are doubts.
Kick off is 7.45pm and Martin Holmes will have LIVE updates tonight on Highland.
Elsewhere the joint leaders are both away from home, Dundalk head to bottom side Athlone Town with Cork City making their way to Dublin to play UCD.
In the other games, Bohemians face Sligo Rovers, Drogheda Utd meet St Pats and Shamrock Rovers play Bray Wanderers.