The Candystrips are without the suspended defender Shane McEleney and midfielder Shaun Kelly while striker Rory Patterson is unlikely to start as he is still receiving treatment for a back injury.
Manager Peter Hutton may rest some first team regulars with a season-defining FAI Cup semi-final against Shamrock Rovers on the horizon.
The top two Dundalk and Cork City will resume their battle for league honours.
Dundalk go to UCD and Cork are at home to Sligo Rovers.
Elsewhere - Bohemians host Limerick, , Drogheda Utd play Bray Wanderers and St Pat's take on Shamrock Rovers