A 51 year old woman has been killed in a crash on the Milford to Kilmacrennan Road.
The two-vehicle collision happened at about quarter past two this morning.
A 50 year old man travelling with her was taken to Letterkenny General hospital and is said to be in a serious condition.
A man and woman who were in the other car are also in a serious condition in hospital.
Milford Superintendant, Eugene McGovern, appealed for anyone who may have been on the main street in MIlford prior to the accident to come forward: