Emergency services are currently at the scene of a road traffic crash between the Kilross junction and Drumkeen.
The collision involving a car and a van happened shortly before 7 o'clock this morning.
The extent of injuries to the occupants of either vehicle is not yet known but motorists are advised to exercise extreme care when approaching the area this morning.
The stretch of road between Letterkenny and Ballybofey is closed and local diversions are in place.
There are no further details at this stage.